Aceclofenac - Medicines Use for Relief of Pain

By: Medicines Tips | Views: 348 | Date: 01-Jan-2014

Aceclofenac is used to relieve the pain and inflammation caused by rheumatoid arthritis, osteoarthritis or ankylosing spondylitis. It works by blocking a substance in the body called cyclo-oxygenase (also known as COX) which is involved in the production of irritant chemicals in conditions such as arthritis. By blocking the action of COX, aceclofenac reduces the symptoms of pain and inflammation.




Aceclofenac - Medicines Use for  Relief of Pain




Type of medicine     Non-steroidal anti-inflammatory drug (NSAID)
Used for     Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis

Aceclofenac is used to relieve the pain and inflammation caused by rheumatoid arthritis, osteoarthritis or ankylosing spondylitis. It works by blocking a substance in the body called cyclo-oxygenase (also known as COX) which is involved in the production of irritant chemicals in conditions such as arthritis. By blocking the action of COX, aceclofenac reduces the symptoms of pain and inflammation. 


This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation. 

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Aceclofenac - List of Branded Medicines & Manufacturer


Before taking aceclofenac make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you are under 18 years of age or over 65 years of age.
  • If you have liver or kidney problems.
  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer.
  • If you have heart problems.
  • If you have ever had blood clotting problems.
  • If you have blood in your stools.
  • If you have a rare blood disorder known as porphyria.
  • If you have systemic lupus erythematosus (an inflammatory condition also called lupus or SLE).
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • If you have ever had an allergic or unusual reaction to any other NSAID (this includes aspirin, naproxen, diclofenac and ibuprofen) or to any other medicine.
  • Before starting aceclofenac, read the manufacturer's printed information leaflet from inside the pack.
  • Take aceclofenac exactly as your doctor has told you.
  • The usual dose is one tablet in the morning and one in the evening. Take aceclofenac tablets with plenty of water, during or straight after a meal.
  • Try to take your doses of aceclofenac at the same times each day to avoid missing any doses.
  • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a missed dose.
  • Keep your regular doctor's appointments so your progress can be monitored.
  • If you need to take aceclofenac for a long time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.
  • If you buy any medicines, check with a pharmacist that they are safe to take with aceclofenac.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Indigestion, heartburn, stomach painMake sure you take your dose after a meal. If the discomfort continues, speak with your doctor
Feeling or being sickEat little and often. Stick to simple or bland foods - avoid rich or spicy foods
DiarrhoeaDrink plenty of water to replace the lost fluids
DizzinessMake sure your reactions are normal before driving, operating any machinery or doing any other jobs which could be dangerous if you were not fully alert
Other possible side-effects: headache, nervousness, mood changes, and difficulty sleepingIf any of these become troublesome, speak with your doctor

Important: If you experience any of the following, speak with your doctor immediately or go to your local accident and emergency department without delay:

  • Any sign of bleeding in the stomach or intestine, such as blood in vomit or dark stools.
  • Any shortness of breath, or swelling of the mouth or face.
  • A severe skin rash.
  • A severe headache with a high temperature and a stiff neck.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Generic Name : Aceclofenac
Indication     :     For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Contra Indication     :     Hypersensitivity. GI bleeding. Moderate to severe renal impairment.Last three months of pregnancy.

Caution     :     Patients with GI disease, history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis. Crohns disease, systemic lupus erythmatosus, porphyria, haematopoietic or coagulation disorders. The dose should be reduced in patients with mild to moderate hepatic, renal or cardiac function impairment.

Side Effect     :     Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.




Indication & Dosage Oral
Ankylosing spondylitis, Rheumatoid arthritis, Osteoarthritis
Adult: 100 mg bid.
Hepatic impairment: Reduce initial dose to 100 mg daily .

Special Populations: Reduce initial dose to 100 mg daily in patients with hepatic impairment.
Overdosage Mangagement: Gastric lavage and treatment with activated characoal. Treatment is supportive and symptomatic. Dialysis, haemoperfusion unlikely to be useful.
Contraindications Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.
Special Precautions Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly.
Adverse Drug Reactions Diarrhoea, nausea, dyspepsia, abdominal pain, dizziness, rashes; increased LFTs.
Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.
Drug Interactions May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
Storage Oral: Store below 30°C.
Mechanism of Action Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: 99%.
Excretion: Urine (as hydroxymetabolites); 4 hr (elimination half-life).
Class Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification M02AA25 - aceclofenac ;
M01AB16 - aceclofenac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products. Used in the treatment of inflammation and rheumatism.


Trade Name(s): 
India- Abate-Sr, Abdal, Ac, Acb, Accept, Accept Gel, Aceact, Acebid, Acebloc, Acec, Aceclan, Aceclo, Acedase, Aceden, Acefen, Aceforce, Acelofan, Acelofan-S, Acelom, Acemarc, Acemove, Acemove In, Acemove-Sr, Acenac, Acenal, Acenez, Acent, Acent Gel, Acent-Sd, Acepar-S, Acepar-Sr, Acerap, Acetuff, Acewalk, Acewin-Sr, Acezo-Sr, Achquit, Aci, Acik, Acicloflex, Acidol, Acifact, Acifact-S, Acifact-Sp, Acifact-Sr, Acifon, Acifon-Sr, Acilex , Acilex-Sr, Aciz, Aciz-S, Aciz-Sr, Aclo, Aclocta , Aclofen, Aclog-Sd, Aclonac-Sn, Aclonac-Sr, Aclova-Sr, Acota, Acrea, Ac-Sera, Acufen-Sr, Afesan, Alnase, Alonac, Alonac-S, Aloo-Sr, Alto , Alto Gel, Altraday, Altraflam, Anace, Ankare, Arflur Gel, Arflur Inj, Arflur-100, Aroff, Aroff Bcd, Aroff-Sr, Arrestin, Asera, Asiclo, Asonac, Asonac-200, Asonac-Sr, Astar, Atofen, Avir, Axsol, Canefo, Carnil-Ac, Catrix, Ceco, Celfast-Sr, Cincofen, Clonac, Curejoint, Cynac, Cynac-S, Diplofen, Diplofen G, Dipt, Diptase Ge, Dolochek, Dolokind, Dolokind-S, Doloral, Dolostat, Dolour, Dolowin, Dolowin Ge, Eclonac , Ecnac-Sr, Elfenac-Sr, Elven, Erinac, Esnil, Fastnac-Sr, Fepra, Firstace,Fepra-Sr, Fico, Flago-15, Flamace, Flamace-S, Flamtop-Sr, Flaxinac-S, Flexidol,flexifen, Flexifen SR, Fornac, Fortafen, Fortafen G, Fynac, Genac, Goflam, Goflam-Sd, Hifenac, Hifenac Ge, Hifenac-Sr, Hinac, Humnag Inj, Icenac, Icobit, Icobit-S, Inane-Sr Kairnac, kapinac, Klacee, Kinectine, Labace, Labonac, Letgo, Locet, Lycee-Th, Mahanac, Megadox, Micronac, Micronac G, Micronac-S, Mobiride-S, Movace, Movace-Sr, Movexx, Moviz, Movon-Cr, Nacku , Nacsiv, Nacku-Sr, Naid, Neflo, Niplonac, Niplonac-S, Novoflam-S, Novo-Sr, Nusaid, Nusaid Gel, Octace, Opinac , Otonac-Sr, Painout, Panace, Panace Gel, Parflex Ge, Parflex-Sr, Peale, Peale Gel, Peconac, Peconac-Sp, Powerace, Powerace-M, Powernac, Powernac-S, Synid A, Synovace, Tamonac, Thiosoft-A, Timenac, Topnac, Toroxx-A, Ultranac, Valdone Ge, Valdyace, Valus, Vetory, Voltanec, Vorth-SR, X Tenet, Xadoo, Xtra,Wyace, Xadoo-100, Xidol-Asr, Zacy-Sr, Zerodol, Zynac, Zerodol-S, Zix, Zix-Sr, Zofen.
International- Acebel-P, Acecloben, Aclo.
Why it is prescribed (Indications) : 
This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation. 
When it is not to be taken (Contraindications): 
Contraindicated in patients with severe ulcer, gastrointestinal bleeding, and hypersensitivity.

Pregnancy Category :

Category N : Not yet classified.

Dosage & When it is to be taken : 
Adult- PO- The recommended dose is 100 mg twice daily.
How it should be taken : 
It comes as a tablet to take by mouth, with food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of Crohn's disease, bruising, heart, liver, or kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, elderly, during pregnancy, alcohol-dependent patients, and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Diarrhea, nausea, headache, indigestion, heartburn, abdominal pain, flatulence, feeling sick, dizziness and rash.

Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in an airtight container in a cool dry place. Protect from light.


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Aceclofenac - List of Branded Medicines & Manufacturer

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Date: 08-Feb-2014  Views: 105

This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation.


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